It is already evident that natural modified DNA bases and their associated enzymology are of fundamental importance to normal biology and to disease.
The next decade promises to yield more insights, discoveries and applications from this burgeoning field of research.. Describes the development of a sequencing method that, for the first time, enabled the study of the dynamics and sequence context of 5hm C in m ES cells at single-base resolution.
Hereafter I hope to elucidate at length these phenomena of expression.
Instead of elucidating the mystery, this knowledge only rendered it more inexplicable.
Bacteriologist, perform your share in elucidating this difficulty.
For example, chemical and enzymatic methods have provided the means to detect and decode modified bases, giving rise to an expanding array of sequencing approaches.
Advanced liquid chromatography and tandem mass spectrometry have provided the means to detect and quantify modified bases with very high sensitivity, increasing the prospect of discovering unknown modifications.